akpwood.blogg.se - Alprazolam overdose antidote

Continuous IV infusion suggested rate 0.1-0.5mg/hr IV up to 1.5mg/hr IV. If initial benefit, maintenance dose may be considered.Repeat in 60-second intervals until desired effect. Patients with anticholinergic symptoms (e.g., tachycardia, hypotension, hypoxia, ECG changes, hyperreflexia, increased muscle tone, dyskinesias).Patients with benzodiazepine dependence (controversial).

Mixed overdose (especially with TCAs or substances that may cause seizure or cardiac dysrhythmias).

Limited role in benzodiazepine and “Z-drug” toxicity.

It has a benefit for ventilation, but this is poorly understood.įlumazenil is controversial in benzodiazepine toxicity as it may increase the risk of ventricular dysrhythmias and seizures, the latter of which may be difficult to treat. It may reverse paradoxical agitation effects as well. It reverses sedative, amnestic, anticonvulsant, anxiolytic, and muscle relaxant effects of benzodiazepines.

It has action against benzodiazepines and “Z-drugs”. It is a competitive antagonist at benzodiazepine receptors in the CNS. Flumazenil is the antidote for benzodiazepines.